abstract：BACKGROUND:Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease in the central nerve system, in which both innate and adaptive immune cells are involved. BBR3378, an aza-anthrapyrazole prevents experimental autoimmune encephalomyelitis (EAE), an inflammatory condition similar to MS, by antagonizing T...

journal_title：Multiple sclerosis and related disorders

authors： Lin B,Launder D,Bailey DY,Assifuah FK,Miller OA,Conti HR,Du J,Koffman BM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Neuromyelitis Optica Spectrum Disorder (NMOSD), commonly characterized by affecting optic nerves and spinal cord can be regarded as one of uncommon diseases of the central nervous system. Although the evidence presented in the literature supports cognitive impairments, psychological aspects of the disease an...

journal_title：Multiple sclerosis and related disorders

authors： Ebadi Z,Saeedi R,Hashemi SN,Gheini MR,Sahraian MA,Naser Moghadasi A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Previous studies have shown an effect of tonsillectomy and greater risk for future autoimmune diseases. Currently there are only few outdated analyses of tonsillectomy and multiple sclerosis (MS) risk. OBJECTIVE:To investigate the prevalence of tonsillectomy in MS patients and healthy controls (HCs). METHO...

journal_title：Multiple sclerosis and related disorders

authors： Jakimovski D,Ahmed MK,Vaughn CB,Zivadinov R,Weinstock-Guttman B

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Coronavirus disease 19 (COVID-19) is a novel disease entity that is spreading throughout the world. It has been speculated that patients with comorbidities and elderly patients could be at high risk for respiratory insufficiency and death. Immunosuppression could expose infected patients to even higher risks...

journal_title：Multiple sclerosis and related disorders

authors： Novi G,Mikulska M,Briano F,Toscanini F,Tazza F,Uccelli A,Inglese M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Treatment decisions in patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic are challenging. It is not known whether and how various disease modifying therapies, especially immunosuppressive drugs, affect COVID-19 risk and disease course. METHODS:Case report RESULTS:...

journal_title：Multiple sclerosis and related disorders

authors： Valencia-Sanchez C,Wingerchuk DM

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Myelin oligodendrocyte glycoprotein (MOG) is an important marker on the surface of oligodendrocytes and is associated with many demyelinating diseases. Recently, MOG-IgG-associated encephalomyelitis (MOG-EM) has been proposed as a disease entity with a preliminary diagnosis standard. Some patients with lung ...

journal_title：Multiple sclerosis and related disorders

authors： Li K,Zhan Y,Shen X

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Fingolimod (Gilenya, Novartis, Basel Switzerland) 0.5 mg orally once-daily is widely used for relapsing-remitting multiple sclerosis. Patients are usually screened four months after starting fingolimod for fingolimod-associated macular oedema (FAME). Large registration trials with stringent eligibility crite...

journal_title：Multiple sclerosis and related disorders

authors： Goh LY,Kirthi V,Silber E,Harvey JP,Jackson TL

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Many natalizumab treated patients experience end of dose interval (EDI) symptoms towards the end of the administration cycle. Natalizumab has previously shown to influence cytokine profiles in relapsing remitting MS patients. We hypothesize that EDI symptoms might be explained by variability in serum cytokin...

journal_title：Multiple sclerosis and related disorders

authors： Cathérine D,Annelien P,Anne S,Luc A,Liesbeth VH,Gerlo S,Guy L

更新日期：2020-06-01 00:00:00

abstract：:Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a common cause of inherited stroke in young adults. CADASIL causes extensive white matter T2 hyperintensities at brain MRI, in particular involving anterior-temporal lobes and external capsules; usually, there is no...

journal_title：Multiple sclerosis and related disorders

authors： Motolese F,Rossi M,Gangemi E,Bersano A,Scelzo E,Di Lazzaro V,Capone F

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:To determine and compare comorbidity levels in the multiple sclerosis (MS) population in Poland using a matched cohort from the general population. METHODS:We compared our database (standardized medical histories and medical records) from a MS center at the Department of Neurology, Medical University of Bia...

journal_title：Multiple sclerosis and related disorders

authors： Kapica-Topczewska K,Tarasiuk J,Chorąży M,Czarnowska A,Brola W,Szczepański M,Kochanowicz J,Kułakowska A

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:In 2001, we conducted a survey on use of complementary and alternative medicine (CAM) in people with multiple sclerosis (pwMS) in Oregon and Southwest Washington to treat their disease. OBJECTIVES, METHODS:In 2018, we administered a revised survey in the same region to describe updated patterns of CAM use i...

journal_title：Multiple sclerosis and related disorders

authors： Silbermann E,Senders A,Wooliscroft L,Rice J,Cameron M,Waslo C,Orban A,Chase E,Yadav V,Bourdette D,Spain RI

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Aquaporin 4 (AQP4)- and myelin oligodendrocyte glycoprotein (MOG)-associated neuromyelitis optica spectrum disorders (NMOSD) are thought to primarily affect the central nervous system (CNS). However, emerging evidence suggests that there are extra-CNS manifestations of NMOSD, including myopathies, gastrointe...

journal_title：Multiple sclerosis and related disorders

authors： Tugizova M,Feng H,Tomczak A,Steenerson K,Han M

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To what extent depression may negatively impact successful aging with multiple sclerosis (MS) is not known. We examined the impact of depression/depressive symptoms on lifestyle choices (diet, exercise, smoking and alcohol), participation and health-related quality of life (HRQoL) among older people living with...

journal_title：Multiple sclerosis and related disorders

authors： Ploughman M,Wallack EM,Chatterjee T,Kirkland MC,Curtis ME,Health Lifestyle and Aging with MS Consortium.

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:It has been suggested that comorbidity in subjects with multiple sclerosis (MS) increases the risk of hospitalizations, although few studies have examined this, and rarely in an incident population. METHODS:Incident MS cases were identified retrospectively from administrative data in Saskatchewan, Canada (1...

journal_title：Multiple sclerosis and related disorders

authors： Al-Sakran L,Marrie RA,Blackburn D,Knox K,Evans C

更新日期：2020-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination and neurodegeneration in the central nervous system. Recent studies suggested that patients with MS might have a greater risk of ischaemic stroke (IS). IS treatment with intravenous alteplase (IVA) in MS has rarely been reported....

journal_title：Multiple sclerosis and related disorders

authors： de Falco A,De Simone M,d'Onofrio F,Spitaleri D,de Falco FA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Olfactory dysfunction is a known clinical feature of multiple sclerosis (MS). Some studies have shown that odor identification impairment is an essential feature associated with cognitive function in MS. This study investigates the relationship between olfactory identification and the disease state, includin...

journal_title：Multiple sclerosis and related disorders

authors： Okada K,Kakeda S,Tahara M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Pain can interfere with the daily functioning of persons with multiple sclerosis (PwMS). Furthermore, beliefs about pain and activity engagement are reliably associated with persons' experience of chronic pain. This study aimed to explore the extent to which different aspects of PwMS' activity engagement is ...

journal_title：Multiple sclerosis and related disorders

authors： Gromisch ES,Kerns RD,Beauvais J

更新日期：2020-02-01 00:00:00

abstract：:The identification of AQP4-IgG, a specific and pathogenic antibody of NMO/SD has led to a broadening of the clinical spectrum of manifestations of NMO/SD including the presence of encephalic symptoms. Lesions are often distributed on peri‑ependymal area and sometimes affected the diencephalon leading to sleep disorder...

journal_title：Multiple sclerosis and related disorders

authors： Beigneux Y,Arnulf I,Guillaume-Jugnot P,Leu-Semenescu S,Maillart E,Lubetzki C,Benveniste O,Papeix C

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To evaluate the effect of intravenous immunoglobulins (IVIG) on prevention of postpartum relapses in women with relapsing-remitting multiple sclerosis (RRMS). METHODS:This was a retrospective study performed in Ljubljana, Slovenia where the practice for all pregnant women with RRMS is to receive IVIG after ...

journal_title：Multiple sclerosis and related disorders

authors： Horvat Ledinek A,Brecl Jakob G,Jerše J,Ruška B,Pavičić T,Gabelić T,Barun B,Adamec I,Rot U,Šega Jazbec S,Krbot Skorić M,Habek M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The presence of white mater lesions in the central nervous system forces the differential diagnosis between multiple sclerosis (MS) and Anderson-Fabry disease (FD). Due to the type of inheritance, linked to the X chromosome, the diagnosis of FD is especially difficult in women. Tissue´s deposits of globotria...

journal_title：Multiple sclerosis and related disorders

authors： Olivera S,Iñiguez C,García-Fernández L,Sierra JL,Camón AM,Menao S,Torralba MÁ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Cognitive impairment is common in multiple sclerosis (MS), but deficits tend to be more pronounced in progressive MS, negatively impacting daily functional capacity. Despite this, most cognitive rehabilitation (CR) interventions to date have focused on relapsing-remitting MS (RRMS). Moreover, information on ...

journal_title：Multiple sclerosis and related disorders

authors： Messinis L,Kosmidis MH,Nasios G,Konitsiotis S,Ntoskou A,Bakirtzis C,Grigoriadis N,Patrikelis P,Panagiotopoulos E,Gourzis P,Malefaki S,Papathanasopoulos P

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Considering the multiple treatments approved for multiple sclerosis (MS) by the Food and Drug Administration (FDA) and European Medicines Agency (EMA), determining a treatment strategy for patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) can be challenging. To date, an overv...

journal_title：Multiple sclerosis and related disorders

authors： Visser LA,Louapre C,Uyl-de Groot CA,Redekop WK

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Cognitive impairment is highly prevalent in multiple sclerosis (MS). Due to the lack of specialized neuropsychological resources in many MS clinics, a brief cognitive monitoring tool that can be administered by other MS clinic staff is needed. BICAMS (Brief International Cognitive As-sessment for Multiple Sc...

journal_title：Multiple sclerosis and related disorders

authors： Marstrand L,Østerberg O,Walsted T,Skov AC,Schreiber KI,Sellebjerg F

更新日期：2020-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is the most common acquired demyelinating disorder of the central nervous system (CNS). Diagnosing MS can be very challenging owing to its variable clinical features and lack of specific tests. Magnetic resonance imaging (MRI) is a key measure in this process. Although white matter lesions on b...

journal_title：Multiple sclerosis and related disorders

authors： Wildner P,Stasiołek M,Matysiak M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Several disease-modifying therapies (DMT) are being used in paediatric patients with multiple sclerosis (MS) despite the limited number of randomised controlled clinical trials leading to approved indication in children. OBJECTIVES:The aim of this study was to describe clinical characteristics of the Danish...

journal_title：Multiple sclerosis and related disorders

authors： Erdal JL,Kopp TI,Blinkenberg M,Petersen T,Sørensen PS,Magyari M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Impairments in long-term and working memory are widespread in Multiple Sclerosis (MS), setting on in early disease stages. These memory impairments may limit patients' ability to take informed and competent medical decisions, too. In healthy populations, memory abilities predict decision quality across a wid...

journal_title：Multiple sclerosis and related disorders

authors： Hoffmann JA,Bareuther L,Schmidt R,Dettmers C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The frequency and long-term prognosis of relapsing multiple sclerosis (RMS) never receiving disease-modifying treatment (DMT) is unclear. METHODS:We included 1186 RMS patients with a mean of 17.4 years follow-up and divided them into patients treated with any DMT (DMT) and patients untreated by shared (USD)...

journal_title：Multiple sclerosis and related disorders

authors： Bsteh G,Hegen H,Dosser C,Auer M,Berek K,Wurth S,Zinganell A,Di Pauli F,Deisenhammer F,Berger T

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:Balance impairment is common and a risk factor of falls in people with multiple sclerosis (MS). The purpose of this study was to evaluate the relative importance between vision and proprioception in maintaining standing body balance among individuals with MS compared with healthy individuals. METHODS:Thirty...

journal_title：Multiple sclerosis and related disorders

authors： Yang F,Liu X

更新日期：2019-12-20 00:00:00

abstract：INTRODUCTION:Some studies have indicated the importance of considering smoking, vitamin D deficiency and obesity as negative prognostic factors for clinical and MRI outcomes in multiple sclerosis (MS). This study aimed to evaluate the possible effects of these modifiable risk factors on brain MRI lesion burden of patie...

journal_title：Multiple sclerosis and related disorders

authors： Lorefice L,Destro F,Fenu G,Mallus M,Gessa I,Sechi V,Barracciu MA,Frau J,Coghe G,Carmagnini D,Marrosu MG,Saba L,Cocco E

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:There is consistent evidence for higher prevalence of affective disorders, specifically mood and anxiety disorders, in people with MS (PwMS). PURPOSE:The goal of this study was to examine the role of emotion dysregulation in explaining symptoms of depression and anxiety in PwMS. METHODS:Data from 100 PwMS ...

journal_title：Multiple sclerosis and related disorders

authors： Prakash RS,Schirda B,Valentine TR,Crotty M,Nicholas JA

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Anti-CD20 monoclonal antibodies such as ocrelizumab, rituximab, and ofatumumab target B-cell lineage. Clinical trials have demonstrated their effect on reducing both magnetic resonance imaging (MRI) active lesion burden as well as clinical activity. Zytux™ (Rituximab, AryoGen Pharmed) used in the present stu...

journal_title：Multiple sclerosis and related disorders

authors： Naser Moghadasi A,Darki A,Masoumi P,Hashemi SN,Ghadiri F

更新日期：2019-11-01 00:00:00

abstract：:Rituximab is a chimeric anti-CD20 monoclonal antibody that is an effective therapy for multiple sclerosis. Rituximab has been associated with the development of serum sickness (type III hypersensitivity) characterized by arthralgia, fever, and rash during the treatment of other conditions, such as rheumatoid arthritis...

journal_title：Multiple sclerosis and related disorders

authors： Wolf AB,Ryerson LZ,Pandey K,McGettigan BM,Vollmer T,Corboy JR,Alvarez E

更新日期：2019-11-01 00:00:00

abstract：:IMPAIRED: arm function and loss of manual dexterity can lead to decreased independence in activities of daily living in persons with Multiple Sclerosis (MS). In this study we verified the feasibility and efficacy of a serious games approach to supervised upper limb rehabilitation of the more affected arm in persons wi...

journal_title：Multiple sclerosis and related disorders

authors： Jonsdottir J,Perini G,Ascolese A,Bowman T,Montesano A,Lawo M,Bertoni R

更新日期：2019-10-01 00:00:00

abstract：:The Acceptance of Chronic Health Conditions Scale was developed to measure acceptance in chronic health conditions like multiple sclerosis (MS) and has been translated into Swedish (The Swedish Acceptance of Chronic Health Conditions Scale). The purpose of the present study was to evaluate construct validity and test-...

journal_title：Multiple sclerosis and related disorders

authors： Wallin A,Forslin M,Johansson S,Kierkegaard M

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Disease-modifying therapy (DMT) for patients with relapsing-remitting multiple sclerosis (RRMS) have been shown to reduce relapses and new MRI lesions. However, few studies have assessed the impact of discontinuing DMT after a period of disease inactivity. OBJECTIVE:To investigate the impact of DMT disconti...

journal_title：Multiple sclerosis and related disorders

authors： Yano H,Gonzalez C,Healy BC,Glanz BI,Weiner HL,Chitnis T

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:No available assessment tool offers a brief and psychometrically sound way for clinicians to quantify assessment of MS in a typical office visit. The objective of this study was to develop a brief clinician-reported outcome measure of MS signs and symptoms to standardize and quantify assessments that occur du...

journal_title：Multiple sclerosis and related disorders

authors： Matza LS,Stewart KD,Phillips G,Delio P,Naismith RT

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Growing evidence supports the efficacy of restorative cognitive training in people with multiple sclerosis (PwMS), but the effects vary across individuals. Differences in treatment efficacy may be related to baseline individual differences. We investigated clinical characteristics and MRI variables to predic...

journal_title：Multiple sclerosis and related disorders

authors： Fuchs TA,Ziccardi S,Dwyer MG,Charvet LE,Bartnik A,Campbell R,Escobar J,Hojnacki D,Kolb C,Oship D,Pol J,Shaw MT,Wojcik C,Yasin F,Weinstock-Guttman B,Zivadinov R,Benedict RHB

更新日期：2019-09-01 00:00:00

abstract：:Neuromyelitis optica spectrum disorder (NMOSD) is a common neuroinflammatory demyelinating disease associated with aquaporin-4 (AQP4) antibody in the central nervous system. Neurosyphilis is a neurological disease caused by Treponema pallidum infection. NMOSD commonly occurs concurrently with autoimmune diseases. Howe...

journal_title：Multiple sclerosis and related disorders

authors： Chen HQ,Zhang Y,Wang SB,Song YN,Bai MS,Liu KD,Zhu MQ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Patients attending multiple sclerosis (MS) clinics experience less disability compared to previous years. OBJECTIVE:This study was conducted retrospectively examining the patient records of our MS Clinic. The patient records in 1996 were compared to those in 2016. METHODS:Demographic data, duration of dise...

journal_title：Multiple sclerosis and related disorders

authors： Ozakbas S,Cinar BP,Kahraman T,Multiple Sclerosis Research Group.

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Relapsing-Remitting MS (RRMS) Deep Grey Matter (DGM) 5 year changes were examined using MRI measures of volume, transverse relaxation rate (R2*) and quantitative magnetic susceptibility (QS). By applying Discriminative Analysis of Regional Evolution (DARE), R2* and QS changes from iron and non-iron sources w...

journal_title：Multiple sclerosis and related disorders

authors： Elkady AM,Cobzas D,Sun H,Seres P,Blevins G,Wilman AH

更新日期：2019-08-01 00:00:00